References

Scientific References

Articles

References:

1. The European Organization for Research and Treatment of Cancer



Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., de Haes, J. C. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst, 85.

2. Chapter 3 - Cardiovascular Disease in Aging and the Role of Oxidative Stress Aging


Alzaid, F., Patel, V. B., & Preedy, V. R. (2014). Chapter 3 – Cardiovascular Disease in Aging and the Role of Oxidative Stress Aging (pp. 23-38). San Diego: Academic Press.

3. Free radicals, oxidative stress, and antioxidants in human health and disease.


Aruoma, O. I. (1998). Free radicals, oxidative stress, and  antioxidants in human health and disease. Journal of the American Oil Chemists’ Society, 75(2), 199-212.

4. Chapter 4 - Oxidative Stress, Aging and Mitochondrial Dysfunction in Liver Pathology A2



Ayala-Peña, S., & Torres-Ramos, C. A. (2014). Chapter 4 – Oxidative Stress, Aging and Mitochondrial Dysfunction in Liver Pathology A2 – Preedy, Victor R Aging (pp. 39-48). San Diego: Academic Press.

5. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck
cancer patients.


Bairati, I., Meyer, F., Gelinas, M., Fortin, A., Nabid, A., Brochet, F., Roy, J. (2005). Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck
cancer patients. J Clin Oncol, 23.

6. Chapter 16 - Magnesium, Oxidative Stress, and Aging Muscle A2



Barbagallo, M., & Dominguez, L. J. (2014). Chapter 16 – Magnesium, Oxidative Stress, and Aging Muscle A2 – Preedy, Victor R Aging (pp. 157-166). San Diego: Academic Press.

7. Role of oxidative stress and antioxidants in daily nutrition and human health.


Bjørklund, G., & Chirumbolo, S. (2017). Role of oxidative stress and antioxidants in daily nutrition and human health. Nutrition, 33, 311-321.

8. Chapter 7 - Oxidative Stress and Antioxidants in Elderly Women A2



Bremer Boaventura, B. C., & Di Pietro, P. F. (2014). Chapter 7 – Oxidative Stress and Antioxidants in Elderly Women A2 – Preedy, Victor R Aging (pp. 73-79). San Diego: Academic Press.

9. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury



Buchholz, B. M., Kaczorowski, D. J., Sugimoto, R., Yang, R., Wang, Y., Billiar, T. R., Nakao, A. (2008). Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant, 8.

10. Neuroprotective effects of hydrogen saline in neonatal hypoxia–ischemia rat model.


Cai, J., Kang, Z., Liu, K., Liu, W., Li, R., Zhang, J. H., Sun, X. (2009). Neuroprotective effects of hydrogen saline in neonatal hypoxia–ischemia rat model. Brain Research, 1256, 129-137.

11. Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model.



Cai, J., Kang, Z., Liu, W. W., Luo, X., Qiang, S., Zhang, J. H., Li, R. (2008). Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model. Neuroscience Letters, 441(2), 167-172.

12. Oral Administration Of Hydrogen Water Prevents Chronic Allograft Nephropathy In Rat Renal Transplantation.



Cardinal, J. S., Zhan, J., Wang, Y., Sugimoto, R., Tsung, A., McCurry, K. R., Nakao, A. (2009). Oral Administration Of Hydrogen Water Prevents Chronic Allograft Nephropathy In Rat Renal Transplantation. Kidney Int, 77.

13. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model.



Chen, C. H., Manaenko, A., Zhan, Y., Liu, W. W., Ostrowki, R. P., Tang, J., & Zhang, J. H. (2010).Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model.Neuroscience, 169(1), 402-414.

14. The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced by Ischemia-Reperfusion in Rats. Journal of Surgical Research



Chen, H., Sun, Y. P., Hu, P. F., Liu, W. W., Xiang, H. G., Li, Y., Wang, Q. (2011). The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced by Ischemia-Reperfusion in Rats. Journal of Surgical Research, 167(2), 316-322.

15. Effects of radiation and alpha-tocopherol on saliva flow rate, amylase activity, total protein and electrolyte levels in oral cavity cancer.



Chitra, S., & Shyamala Devi, C. S. (2008). Effects of radiation and alpha-tocopherol on saliva flow rate, amylase activity, total protein and electrolyte levels in oral cavity cancer. Indian J Dent Res,19.

16. Radioprotectors and mitigators of radiation-induced normal tissue injury.



Citrin, D., Cotrim, A. P., Hyodo, F., Baum, B. J., Krishna, M. C., & Mitchell, J. B. (2010). Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist, 15.

17. Pathogenesis and treatment of mitochondrial myopathies: recent advances.



DiMauro, S. (2010). Pathogenesis and treatment of mitochondrial myopathies: recent advances. Acta Myologica, 29.

18. Chapter 9 - Enteral Nutrition to Increase Antioxidant Defenses in Elderly Patients A2



Eduardo de Aguilar-Nascimento, J. (2014). Chapter 9 – Enteral Nutrition to Increase Antioxidant Defenses in Elderly Patients A2 – Preedy, Victor R Aging (pp. 93-98). San Diego: Academic Press.

19. Resuscitation of preterm infants with reduced oxygen results in less oxidative stress than resuscitation with 100% oxygen.



Ezaki, S., Suzuki, K., Kurishima, C., Miura, M., Weilin, W., Hoshi, R., . . . Tamura, M. (2009). Resuscitation of preterm infants with reduced oxygen results in less oxidative stress than resuscitation with 100% oxygen. J Clin Biochem Nutr, 44.

20. Chapter 20 - Downregulation of the Prooxidant Heart Failure Phenotype by Dietary and Nondietary Antioxidants A2



Farah, V., Askari, R., Alsafwah, S., Dishmon, D. A., Bhattacharya, S. K., & Weber, K. T. (2014). Chapter 20 – Downregulation of the Prooxidant Heart Failure Phenotype by Dietary and Nondietary Antioxidants A2 – Preedy, Victor R Aging (pp. 203-212). San Diego: Academic Press.

21. Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease.



Fujita, K., Seike, T., Yutsudo, N., Ohno, M., Yamada, H., Yamaguchi, H., . . . Noda, M. (2009). Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease. PLoS One, 4.

22. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochemical and Biophysical Research Communications,



Fukuda, K.-i., Asoh, S., Ishikawa, M., Yamamoto, Y., Ohsawa, I., & Ohta, S. (2007). Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochemical and Biophysical Research Communications, 361(3), 670-674.

23. Chapter 13 - Tryptophan and Melatonin-Enriched Foodstuffs to Improve Antioxidant Status in Aging A2



Garrido, M., Rodríguez, A. B., & Terrón, M. P. (2014). Chapter 13 – Tryptophan and Melatonin-Enriched Foodstuffs to Improve Antioxidant Status in Aging A2 – Preedy, Victor R Aging (pp. 129-136). San Diego: Academic Press.

24. Hydrogen: another gas with therapeutic potential.


George, J. F., & Agarwal, A. Hydrogen: another gas with therapeutic potential. Kidney International, 77(2), 85-87.

25. Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice.



Gu, Y., Huang, C. S., Inoue, T., Yamashita, T., Ishida, T., Kang, K. M., & Nakao, A. (2010). Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. J Clin Biochem Nutr, 46.

26. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury.



Hayashida, K., Sano, M., Ohsawa, I., Shinmura, K., Tamaki, K., Kimura, K., Fukuda, K. (2008). Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury. Biochemical and Biophysical Research Communications, 373(1), 30-35.

27. Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies.


Hong, Y., Chen, S., & Zhang, J.-M. (2010). Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies. Journal of International Medical Research, 38(6), 1893-1903.

28. Recent Advances in Hydrogen Research as a Therapeutic Medical Gas



Huang, C., Kawamura, T., Toyoda, Y., & Nakao, A. (2010). Recent Advances in Hydrogen Research as a Therapeutic Medical Gas. Free Rad Res, 44.

29. Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study.



Ishibashi, T., Sato, B., Shibata, S., Sakai, T., Hara, Y., Naritomi, Y., Nagao, T. (2014). Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study. International Immunopharmacology, 21(2), 468-473.

30. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.



Ito, M., Ibi, T., Sahashi, K., Ichihara, M., Ito, M., & Ohno, K. (2011). Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Medical Gas Research, 1(1), 24.

31. Molecular hydrogensuppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.



Itoh, T., Fujita, Y., Ito, M., Masuda, A., Ohno, K., Ichihara, M., Ito, M. (2009). Molecular hydrogensuppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun, 389.

32. Chapter 15 - S-Equol, an Antioxidant Metabolite of Soy Daidzein, and Oxidative Stress in Aging: A Focus on Skin and on the Cardiovascular System A2



Jackson, R. L., Greiwe, J. S., & Schwen, R. J. (2014). Chapter 15 – S-Equol, an Antioxidant Metabolite of Soy Daidzein, and Oxidative Stress in Aging: A Focus on Skin and on the Cardiovascular System A2 – Preedy, Victor R Aging (pp. 145-155). San Diego: Academic Press.

33. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.



Kajiya, M., Silva, M. J. B., Sato, K., Ouhara, K., & Kawai, T. (2009). Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochemical and Biophysical Research Communications, 386(1), 11-15.

34. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.



Kajiyama, S., Hasegawa, G., Asano, M., Hosoda, H., Fukui, M., Nakamura, N., Yoshikawa, T. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28(3), 137-143.

35. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.


Kang, K.-M., Kang, Y.-N., Choi, I.-B., Gu, Y., Kawamura, T., Toyoda, Y., & Nakao, A. (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 1(1), 11.

36. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.



Kato, S., Saitoh, Y., Iwai, K., & Miwa, N. (2012). Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stressdiminishment in fibroblasts and cell-injury prevention in keratinocytes. Journal of Photochemistry and Photobiology B: Biology, 106, 24-33.

37. Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection.



Kwon, J. H., Bae, S. H., Kim, J. Y., Choi, B. O., Jang, H. S., Jang, J. W., Chung, K. W. (2010). Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer. BMC Cancer, 10.

38. Antioxidants and cancer therapy: a systematic review.



Ladas, E. J., Jacobson, J. S., Kennedy, D. D., Teel, K., Fleischauer, A., & Kelly, K. M. (2004). Antioxidants and cancer therapy: a systematic review. J Clin Oncol, 22.

39. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress.



Li, J., Wang, C., Zhang, J. H., Cai, J.-M., Cao, Y.-P., & Sun, X.-J. (2010). Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Research, 1328, 152-161.

40. Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.



Liu, C., Cui, J., Sun, Q., & Cai, J. (2010). Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses, 74(1), 145-146.

41. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.



Mao, Y.-F., Zheng, X.-F., Cai, J.-M., You, X.-M., Deng, X.-M., Zhang, J. H., Sun, X.-J. (2009). Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochemical and Biophysical Research Communications, 381(4), 602-605.

42. Overview of the Role of Antioxidant Vitamins as Protection Against Cardiovascular Disease: Implications for Aging A2



Maruyama, K., & Iso, H. (2014). Chapter 21 – Overview of the Role of Antioxidant Vitamins as Protection Against Cardiovascular Disease: Implications for Aging A2 – Preedy, Victor R Aging (pp. 213-224). San Diego: Academic Press.

43. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia–ischemia rat models.



Matchett, G. A., Fathali, N., Hasegawa, Y., Jadhav, V., Ostrowski, R. P., Martin, R. D., Zhang, J. H. (2009). Hydrogen gas is ineffective in moderate and severe neonatal hypoxia–ischemia rat models. Brain Research, 1259, 90-97.

44. Chapter 23 - Aging and Arthritis: Oxidative Stress and Antioxidant Effects of Herbs and Spices A2



Mekha, M. S., Shobha, R. I., Rajeshwari, C. U., & Andallu, B. (2014). Chapter 23 – Aging and Arthritis: Oxidative Stress and Antioxidant Effects of Herbs and Spices A2 – Preedy, Victor R Aging (pp. 233-245). San Diego: Academic Press.

45. Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long-term effects on recurrence and mortality: a randomized trial among head and neck cancer patients.



Meyer, F., Bairati, I., Fortin, A., Gelinas, M., Nabid, A., Brochet, F., & Tetu, B. (2008). Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long-term effects on recurrence and mortality: a randomized trial among head and neck cancer patients. Int J Cancer, 122.

46. Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer.



Misirlioglu, C. H., Demirkasimoglu, T., Kucukplakci, B., Sanri, E., & Altundag, K. (2007). Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer. Med Oncol, 24.

47. Chapter 22 - Hypertension, Menopause and Natural Antioxidants in Foods and the Diet.



Modena, M. G. (2014). Chapter 22 – Hypertension, Menopause and Natural Antioxidants in Foods and the Diet A2 – Preedy, Victor R Aging (pp. 225-231). San Diego: Academic Press.

48. Chapter 10 - Herbs and Spices in Aging



Mohamed, S. (2014). Chapter 10 – Herbs and Spices in Aging A2 – Preedy, Victor R Aging (pp. 99- 107). San Diego: Academic Press.

49. Therapeutic Antioxidant Medical Gas.



Nakao, A., Sugimoto, R., Billiar, T. R., & McCurry, K. R. (2009). Therapeutic Antioxidant Medical Gas. J Clin Biochem Nutr, 44.

50. Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study



Nakao, A., Toyoda, Y., Sharma, P., Evans, M., & Guthrie, N. (2010). Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition, 46(2), 140-149.

51. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.



Nakashima-Kamimura, N., Mori, T., Ohsawa, I., Asoh, S., & Ohta, S. (2009). Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol, 64.

52. Biological Effects of Electrolyzed Water in Hemodialysis



Nakayama, M., Kabayama, S., Nakano, H., Zhu, W. J., Terawaki, H., Nakayama, K., Ito, S. (2009). Biological Effects of Electrolyzed Water in Hemodialysis. Nephron Clin Pract, 112.

53. A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis



Nakayama, M., Nakano, H., Hamada, H., Itami, N., Nakazawa, R., & Ito, S. (2010). A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant, 25.

54. Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis.



Nishijima, C., Hayakawa, I., Matsushita, T., Komura, K., Hasegawa, M., Takehara, K., & Sato, S. (2004). Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis. Clin Exp
Immunol, 138.

55. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.


Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature medicine, 13(6), 688-694.

56. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochemical and Biophysical Research Communications.


Ohsawa, I., Nishimaki, K., Yamagata, K., Ishikawa, M., & Ohta, S. (2008). Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochemical and Biophysical Research Communications, 377(4), 1195-1198.

57. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.


Ohta, S. (2012). Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochimica et Biophysica Acta (BBA) – General Subjects, 1820(5), 586-594.

58. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.



Ohta, S. (2014). Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacology & Therapeutics, 144(1), 1-11.

59. Molecular Hydrogen as a Novel Antioxidant: Overview of the Advantages of Hydrogen for Medical Applications.



Ohta, S. (2015). Chapter Fifteen – Molecular Hydrogen as a Novel Antioxidant: Overview of the Advantages of Hydrogen for Medical Applications. In C. Enrique & P. Lester (Eds.), Methods in Enzymology (Vol. Volume 555, pp. 289-317): Academic Press.

60. Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research.



Ohta, S., Nakao, A., & Ohno, K. (2011). The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research. Med Gas Res, 1.

61. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study.



Ono, H., Nishijima, Y., Adachi, N., Tachibana, S., Chitoku, S., Mukaihara, S., Nawashiro, H. (2011). Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Med Gas Res, 

62. The role of antioxidants in the chemistry of oxidative stress: A review. European Journal of Medicinal Chemistry


Pisoschi, A. M., & Pop, A. (2015). The role of antioxidants in the chemistry of oxidative stress: A review. European Journal of Medicinal Chemistry, 97, 55-74.

63. Oxidative Stress in the Elderly and Implications for Inflammation



Prasad, A. S. (2014). Chapter 25 – Zinc, Oxidative Stress in the Elderly and Implications for Inflammation A2 – Preedy, Victor R Aging (pp. 259-275). San Diego: Academic Press.

64. Pros and cons of antioxidant use during radiation therapy.



Prasad, K. N., Cole, W. C., Kumar, B., & Che Prasad, K. (2002). Pros and cons of antioxidant use during radiation therapy. Cancer Treat Rev, 28.

65. Radioprotective effect of hydrogen in cultured cells and mice.



Qian, L., Cao, F., Cui, J., Huang, Y., Zhou, X., Liu, S., & Cai, J. (2010). Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res, 44.

66. The potential cardioprotective effects of hydrogen in irradiated mice


Qian, L., Cao, F., Cui, J., Wang, Y., Huang, Y., Chuai, Y., Cai, J. (2010). The potential cardioprotective effects of hydrogen in irradiated mice. Journal of radiation research, 51(6), 741-747.

67. Lycopene and Other Antioxidants in the Prevention and Treatment of Osteoporosis in Postmenopausal Women



Rao, L. G., Kang, N. N., & Rao, A. V. (2014). Chapter 24 – Lycopene and Other Antioxidants in the Prevention and Treatment of Osteoporosis in Postmenopausal Women A2 – Preedy, Victor R Aging (pp. 247-258). San Diego: Academic Press.

68. The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001



Ringborg, U., Bergqvist, D., Brorsson, B., Cavallin-Stahl, E., Ceberg, J., Einhorn, N., Moller, T. R. (2003). The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001–summary and conclusions. Acta Oncol, 42.

69. Chapter 18 -Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer’s Neurodegeneration



Rosales-Corral, S. A., Reiter, R. J., Tan, D.-X., Manchester, L. C., & Liu, X. (2014). Chapter 18 -Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer’s Neurodegeneration A2 -Preedy, Victor R Aging (pp. 177-193). San Diego: Academic Press.

70. Chapter 17 - Late-Life Depression and Antioxidant Supplements



Rybka, J., Kedziora-Kornatowska, K., van Heesch, F., & Kedziora, J. (2014). Chapter 17 – Late-Life Depression and Antioxidant Supplements A2 – Preedy, Victor R Aging (pp. 167-176). San Diego: Academic Press.

71. Vitamin C and Physical Performance in the Elderly



Saito, K., Hosoi, E., Ishigami, A., & Yokoyama, T. (2014). Chapter 12 – Vitamin C and Physical Performance in the Elderly A2 – Preedy, Victor R Aging (pp. 119-127). San Diego: Academic Press.

72. Prevention of radioinduced cystitis by orgotein: a randomized study.



Sanchiz, F., Milla, A., Artola, N., Julia, J. C., Moya, L. M., Pedro, A., & Vila, A. (1996). Prevention of radioinduced cystitis by orgotein: a randomized study. Anticancer Res, 16.

73. Diabetes as a Disease of Aging, and the Role of Oxidative Stress



Sarkar, D., & Shetty, K. (2014). Chapter 6 – Diabetes as a Disease of Aging, and the Role of Oxidative Stress A2 – Preedy, Victor R Aging (pp. 61-69). San Diego: Academic Press.

74. Metabolic Mobilization Strategies to Enhance the Use of Plant-Based Dietary Antioxidants for the Management of Type 2 Diabetes



Sarkar, D., & Shetty, K. (2014). Chapter 27 – Metabolic Mobilization Strategies to Enhance the Use of Plant-Based Dietary Antioxidants for the Management of Type 2 Diabetes A2 – Preedy, Victor R Aging (pp. 289-296). San Diego: Academic Press.

75. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochemical and Biophysical Research Communications



Sato, Y., Kajiyama, S., Amano, A., Kondo, Y., Sasaki, T., Handa, S., Ishigami, A. (2008). Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochemical and Biophysical Research Communications, 375(3), 346-350.

76. Arthritis as a Disease of Aging and Changes in Antioxidant Status



Saxena, R. (2014). Chapter 5 – Arthritis as a Disease of Aging and Changes in Antioxidant Status A2 – Preedy, Victor R Aging (pp. 49-59). San Diego: Academic Press.

77. Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.



Shen, M., He, J., Cai, J., Sun, Q., Sun, X., & Huo, Z. (2010). Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses, 75(2), 235-237.

78. Protective Effects of Vitamin C on Age-Related Bone and Skin Phenotypes Caused by Intracellular Reactive Oxygen Species



Shibuya, S., Nojiri, H., Morikawa, D., Koyama, H., & Shimizu, T. (2014). Chapter 14 – Protective Effects of Vitamin C on Age-Related Bone and Skin Phenotypes Caused by Intracellular Reactive Oxygen Species A2 – Preedy, Victor R Aging (pp. 137-144). San Diego: Academic Press.

79. Antioxidant Supplementation in the Elderly and Leukocytes



Simar, D., & Caillaud, C. (2014). Chapter 26 – Antioxidant Supplementation in the Elderly and Leukocytes A2 – Preedy, Victor R Aging (pp. 277-287). San Diego: Academic Press.

80. Mitochondria-Targeted Antioxidants and Alzheimer’s Disease



Skulachev, V. P., Isaev, N. K., Kapay, N. A., Popova, O. V., Stelmashook, E. V., Lyamzaev, K. G., Skrebitsky, V. G. (2014). Chapter 19 – Mitochondria-Targeted Antioxidants and Alzheimer’s. Disease A2 – Preedy, Victor R Aging (pp. 195-201). San Diego: Academic Press.

81. Skin Aging and Oxidative Stress



Starr, J. M., & Starr, R. J. (2014). Chapter 2 – Skin Aging and Oxidative Stress A2 – Preedy, Victor R Aging (pp. 15-22). San Diego: Academic Press.24-33.

82. How matrix metalloproteinases regulate cell behavior



 Sternlicht, M. D., & Werb, Z. (2001). How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol, 17.

83. The protective role of hydrogen- rich saline in experimental liver injury in mice.



Sun, H., Chen, L., Zhou, W., Hu, L., Li, L., Tu, Q., Wu, M. (2011). The protective role of hydrogen- rich saline in experimental liver injury in mice. Journal of hepatology, 54(3), 471-480.

84. Melatonin as a radioprotective agent: a review.



Vijayalaxmi, Reiter, R. J., Tan, D. X., Herman, T. S., & Thomas, C. R. (2004). Melatonin as a radioprotective agent: a review. Int J Radiat Oncol Biol Phys, 59.

85. Antioxidants, Vegetarian Diets and Aging.



Wachtel-Galor, S., Siu, P. M., & Benzie, I. F. F. (2014). Chapter 8 – Antioxidants, Vegetarian Diets and Aging A2 – Preedy, Victor R Aging (pp. 81-91). San Diego: Academic Press.

86. Oxidative stress



Wei, Y. H., Lu, C. Y., Wei, C. Y., Ma, Y. S., & Lee, H. C. (2001). Oxidative stress

87. In human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system.



In human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system. Chin J Physiol, 44.

88. Oxidative Stress and Frailty: A Closer Look at the Origin of a Human Aging Phenotype



Wu, I. C., Hsiung, C. A., Hsu, C.-C., & Lin, X.-Z. (2014). Chapter 1 – Oxidative Stress and Frailty: A Closer Look at the Origin of a Human Aging Phenotype A2 – Preedy, Victor R Aging (pp. 3-14). San Diego: Academic Press.

89. Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.



Xavier, S., Yamada, K., Samuni, A. M., Samuni, A., DeGraff, W., Krishna, M. C., & Mitchell, J. B. (2002). Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage. Biochim Biophys Acta, 1573.

90. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.



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91. Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications


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92. Coenzyme Q10 as an Antioxidant in the Elderly



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93. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion



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99. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells


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About Hyzumi

“We strive to educate and spread the wonders of living a hydrogen healthy lifestyle, for everyone.”

Hyzumi is a Malaysian brand of exceptionally made hydrogen water generators founded with Japanese patented technology to enrich your water with unlimited hydrogen supply to re-balance your health.

Hyzumi worked tirelessly since 2017 with Japanese partners, Ozawa and Nagae, in collaboration with Chugoku Electric Manufacturing Co. Inc with the successful  transfer of Japanese patented technology and knowledge to develop safe, high quality and innovative products.

[Photo] Miss Yap (General Manager / Co-Founder], Mr Yeap, Mr Ozawa (Partner / Inventor), Mr Nagae Senior, Mr Nagae Junior.

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